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KMID : 0604520110370020191
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Journal of the Society of Cosmetic Scientists of Korea
2011 Volume.37 No. 2 p.191 ~ p.198
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Antioxidative Activities and Antiaging Effects of Geum aleppicum Jacq. Extracts
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Kim Min-Ji
Yang Hyun-Gab
Park Soo-Nam
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Abstract
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In this study, antioxidative effects and inhibitory effects of Geum aleppicum Jacq. extracts on tyrosinase and elastase were investigated. The ethyl acetate fraction of G. aleppicum Jacq. extract (4.70㎍/mL) showed the most prominent free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) scavenging activity (FSC??). Reactive oxygen species (ROS) scavenging activities (OSC??) of some G. aleppicum Jacq. extracts on ROS generated in Fe³＋－EDTA/H₂O₂system were investigated using the luminol-dependent chemiluminescence assay. The ethyl acetate fraction showed the most prominent ROS scavenging activity (0.22㎍/mL). The protective effects of extract/fraction of G. aleppicum Jacq. against the rose-bengal sensitized photohemolysis of human erythrocytes were investigated. The G. aleppicum Jacq. extracts suppressed photohemolysis in a concentration dependent manner (1~25㎍/mL), particularly the ethyl acetate fraction exhibited the most prominent celluar protective effect (τ??, 416.20 min at 10㎍/mL). The inhibitory effect of G. aleppicum Jacq. extracts on tyrosinase and elastase were investigated to assess their whitening and anti-winkle efficacy. The half maximal inhibitory concentration (IC??) of the ethyl acetate fraction on tyrosinase was 95.23㎍/mL. The IC?? of 50 % ethanol extract and the ethyl acetate fraction on elastase were 6.27㎍/mL and 4.31㎍/mL, respectively. These results indicate that extract/fraction of G. aleppicum Jacq. can function as antioxidants in biological systems, particularly skin exposed to UV radiation by scavenging ¹O₂ and other ROS, and protect cellular membranes against ROS. Especially the ethyl acetate fraction of G. aleppicum Jacq. extracts could be applicable to new functional cosmetics for antioxidant, antiaging.
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KEYWORD
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Geum aleppicum Jacq., reactive oxygen species, antioxidative activity, antiaging, cosmetics
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